the role of human microRNAs as a potential antiviral mechanism against Human
Immunodeficiency Virus (HIV) and suggested the molecular mechanism of the
role of microRNAs as a critical determinant of long-term non-progression
(LTNP) states. Also suggested microRNA level variation to have prognostic
value (Biochem Biophys Res Commun.
2005).This work has been extensively cited in top journals including a
news and views article in Nature Reviews Drug Discovery.
Suggested a comprehensive model for microRNA
mediated host-virus interaction and suggested
design and use of artificial microRNAs as a therapeutic (Retrovirology 2006).
for the first time, an algorithm for design of highly specific artificial
microRNAs. This tool is being experimentally validated.
Developed an algorithm and designed Oligonucleotide enzymes (10-23 DNAzymes) which can specifically cleave microRNAs (aka AnatagomiRzyme). The methodology and experimental validation is available at Jadhav et al, Angewandte Chemie 2009.
Whole Genome Sequencing and Annotation of the Wild-Type Strain of Zebrafish (2009) (In Collaboration with Dr.Sridhar Sivasubbu/IGIB) Comprehensive annotation of the genome, variome and transcriptome of zebrafish.
Has been one of the pioneers of Open
Access movement in the country, and has been an invited contributor to Open
Access News. Developed one of the
first and largest databases of Medical Libraries on the Internet (MedLib)
while in medical school. This has been extensively acknowledged including British Medical Journal
E-Health and E-Health ethics research in the country and pioneered one of
the first studies on Cyber-pharmacies and public access of health information.
Also played major role in establishing one of the first E-Health groups in
the country while in medical school. The group later evolved into a full
fledged Telemedicine and E-Health facility at Calicut Medical
published have been cited in top Journals in the field.
Was awarded Gold Medals for best student in university for Biochemistry and
Peer reviewer, editorial board member,
advisor of various National and International journals including PLoS
journals , Bioinformatics(Oxford) and Frontiers in Biosciences.