Genomics for Precision Medicine in Arab and Middle Eastern Populations



Precision Medicine
is a new concept and an emerging model of healthcare where the genetic makeup and its interaction with the environment in incorporated towards enabling prevention, precise diagnosis and prognostication as well as precise treatment and management of a disease or condition.

A number of diseases are quite prevalent in the Arab world which spans Middle East and North Africa. A large part of this is attributed to the widespread practice and norm of consanguinity in the region. Understanding the genetic characteristics of many such diseases would provide the much necessary knowledge to build an effective healthcare system where early screening, early diagnosis and effective management can significantly reduce the morbidity and mortality due to such diseases.

Contribute to DALIA / Disease Alleles in Arabs
While a number of publications from this region have described genetic variants associated with diseases, many of these variants have not been adequately represented in global databases. The Disease Alleles in Arabs (dalia) is a unique venture to fill in this gap. 

Genomic Resources
Our collaborations have contributed to building a number of genomic resources which are extensively used by researchers and clinicians.
http://clingen.igib.res.in/almenaComprehensive resource of genetic variants associated with diseases in Arabs


Research Highlights

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Collaborating on Genomics
We have been working over a decade with an extensive number of collaborators with interests spanning clinical genomics and basic sciences. Our relationships are built on mutual respect, trust and willingness to learn from each other and a common goal to advance genomics. This has impacted our research in a variety of ways, significantly improving our reach, outlook and applications. Our partners have also similarly been impacted through leveraging the support, knowledge base and network and see us as partners towards delivering world-class research and clinical services.

Why you should collaborate with us.
  • Our collaborators have access to a wide array of high-throughput genomics instrumentation to support their various needs, including genotyping and next generation sequencing.
  • Access and exposure to well-standardised data analysis pipelines customised to solve your needs and personalised to suit your specific requirements
  • Experience and knowledge base which has resulted in over 100 publications in peer reviewed journals, which comes a long way to showcase your research.
  • Proven track record in leveraging support to advance your science, through inputs, discussions which can enrich your scientific research, manuscripts as well as grant applications.

Research in Media

Qatar exome study: An advancement in precision medicine
Louise Sarant in Nature Middle East

Scientists have used information from the whole-exome sequencing of 100 Qataris to create a comprehensive map of pharmacogenetic variants associated with two anticoagulants. [read more]

Recent Publications

Personalized Medicine (2017) DOI: 10.2217/pme-2017-0048

Koshy R, Sivadas A, Scaria V.
Genetic epidemiology of Familial Mediterranean Fever through integrative analysis of whole genome and exome sequences from Middle East and North Africa
Clinical Genetics (2017) DOI: 10.1111/cge.13070

Koshy R, Ranawat A, Scaria V.
al mena - a comprehensive resource of human genetic variants integrating genomes and exomes from Arab, Middle Eastern and North African populations.
Journal of Human Genetics (2017) 62, 889–894; DOI:10.1038/jhg.2017.67


Sandhya P, Vellarikkal SK, Nair A, Ravi R, Mathew J, Jayarajan R, Kumar A, Verma A, Sivadas A, Danda D, Sivasubbu S*, Scaria V*
Int J Rheum Dis (2017) DOI: 10.1111/1756-185X.13042

Sivadas A, Sharma P, Scaria V
Landscape of warfarin and clopidogrel pharmacogenetic variants in Qatari population from whole exome datasets
Pharmacogenomics (2016) Accepted doi: 10.2217/pgs-2016-0130