Genomics for Precision Medicine in Arab and Middle Eastern Populations



Precision Medicine
is a new concept and an emerging model of healthcare where the genetic makeup and its interaction with the environment in incorporated towards enabling prevention, precise diagnosis and prognostication as well as precise treatment and management of a disease or condition.

A number of diseases are quite prevalent in the Arab world. A large part of this is attributed to the widespread practice and norm of consanguinity in the region. Understanding the genetic characteristics of many such diseases would provide the much necessary knowledge to build an effective healthcare system where early screening, early diagnosis and effective management cans significantly reduce the morbidity and mortality due to such diseases.


Landscape of Pharmacogenetic variants - Towards Precision Medicine in Qatar

Pharmacogenetic landscapes of commonly used anti-platelet drugs, warfarin and clopidogrel has been studied in-depth in many countries. However, there is a paucity of data to understand their patterns in the Arab populations. We characterized the allelic distribution of variants routinely tested for warfarin and clopidogrel in the publicly available whole exome sequencing datasets of 100 Qatar individuals . Our analysis points to ethnic differences in the frequencies of pharmacogenetics variants even for the small population studied. To the best of our knowledge, this is one of the first and most comprehensive pharmacogenetic maps of variants associated with warfarin and clopidogrel for an Arab population, which can help tailor the drug dosage to the population.


Sivadas A, Sharma P, Scaria V
Landscape of warfarin and clopidogrel pharmacogenetic variants in Qatari population from whole exome datasets
Pharmacogenomics (2016) Accepted doi: 10.2217/pgs-2016-0130

Characterizing the Arab Human Variome by data integration of studies from Middle East and North Africa

There have been multiple efforts to charecterise the Arab Human Variome. We have integrated over 26 million variants derived from integration of multiple whole genome and whole exome studies from the region in a comprehensive database - AL MENA (Alleles in Middle East and North Africa). The present version of the database provides information on Apart from providing the allele frequencies for the genetic variants, this unique resource also provides relevant annotations for clinically relevant genetic variants.

Koshy R, Ranawat A, Scaria V.
al mena - a comprehensive resource of human genetic variants integrating genomes and exomes from Arab, Middle Eastern and North African populations.
Journal of Human Genetics (2017) Accepted
Resource URL http://clingen.igib.res.in/almena/
The resource is exclusively for Academic use. 



Research in Media

Qatar exome study: An advancement in precision medicine
Louise Sarant in Nature Middle East

Scientists have used information from the whole-exome sequencing of 100 Qataris to create a comprehensive map of pharmacogenetic variants associated with two anticoagulants. [read more]

Research Highlights

  • Integrating genetic variants in Middle East, Arab and North African populations towards Precision Medicine Precision Medicine is a new concept and an emerging model of healthcare where the genetic makeup and its interaction with the environment in incorporated towards enabling prevention, precise diagnosis and ...
    Posted May 20, 2017, 7:01 AM by Vinod Scaria
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Publications

Koshy R, Ranawat A, Scaria V.
al mena - a comprehensive resource of human genetic variants integrating genomes and exomes from Arab, Middle Eastern and North African populations.
Journal of Human Genetics (2017) Accepted

Sandhya P, Vellarikkal SK, Nair A, Ravi R, Mathew J, Jayarajan R, Kumar A, Verma A, Sivadas A, Danda D, Sivasubbu S*, Scaria V*
An Egyptian tale from India - application of whole-exome sequencing in diagnosis of atypical Familial Mediterranean Fever
Int J Rheum Dis (2017) Accepted

Sivadas A, Sharma P, Scaria V
Landscape of warfarin and clopidogrel pharmacogenetic variants in Qatari population from whole exome datasets
Pharmacogenomics (2016) Accepted doi: 10.2217/pgs-2016-0130