Disease Alleles in Arabs (DALIA) - a comprehensive resource of genetic variants associated with genetic diseases

posted Sep 24, 2018, 10:00 PM by Vinod Scaria   [ updated Sep 24, 2018, 10:00 PM ]
The Arab world encompassing Middle East and North Africa is home to over 350 million people. This approximately represents over 5% of the world population and is characterized by significant ethnic, linguistic and genetic diversity, while encompassing similarities in language, traditions, cultural practices as well as geographic proximity. 

A number of diseases are quite prevalent in the Arab world. A large part of this is attributed to the widespread practice and norm of consanguinity in the region. Understanding the genetic characteristics of many such diseases would provide the much necessary knowledge to build an effective healthcare system where early screening, early diagnosis and effective management can significantly reduce the morbidity and mortality due to such diseases.

While a number of publications from this region have described genetic variants associated with diseases, many of these variants have not been adequately represented in global databases. The Disease Alleles in Arabs (dalia) is a unique venture to systematically characterize evidence from literature to build a comprehensive catalog of disease associated variants in the region.