Genomics of COVID-19 Reinfection


Publications
Gupta, V., Bhoyar, R. C., Jain, A., Srivastava, et al, 
Accepted (2020) 
OSF Preprints https://doi.org/10.31219/osf.io/4fmrg [Preprint]

Preprints are not peer reviewed publications and are shared for enabling early access and open discussion. 

Contact
Dr Sridhar Sivasubbu sridhar@igib.in
Dr Vinod Scaria vinods@igib.in 
About this Programme
Re-infection of SARS-CoV-2 is a rare entity and sometimes considered controversial. There have been only a few reports of SARS-CoV-2 re-infection reported from across the world. It is widely believed that genetic variants in the SARS-CoV-2 genome are responsible for re-infection. No data is yet available on host factors responsible for re-infection, though some evidence points to the key role of germinal centre development and re-infection, suggesting a potential subtle primary or secondary immunodeficiency.

This research programme aims to track cases of reported COVID-19 re-infection and understand the genetic basis and biology of COVID-19 re-infection. 

This research is co-ordinated by researchers Dr Vinod Scaria and Dr Sridhar Sivasubbu at the CSIR Institute of Genomics and Integrative Biology (CSIR-IGIB). email us at vinods@igib.in ; sridhar@igib.in for any clarifications or assistance regarding this programme.

COVID-19 Reinfection in Press and Media
Scientists document cases of asymptomatic COVID-19 reinfection. THE HINDU Sep 15, 2020
How to Refer

STEP 1 LET US KNOW
Please fill in the online proforma to let us know about someone under your care or you know with COVID-19 re-infection. We would get back to you with the details and documentation and information on the logistics.

STEP 2 REFERRAL
Referral requires the following
Patient Consents
Samples: 
RNA sample from NP swabs from previous and present COVID-19 infection. 
Blood sample (5ml) 
Clinical Details required
Clinical notes and investigation summaries from previous and present COVID-19 treatments. We follow the ISARIC CORE Case report format

STEP 3 SAMPLE TRANSPORT AND LOGISTICS
We would arrange for the sample transport and logistics of the samples from your office. We would get back to you with details on the same.The referral should not cost you anything.

STEP 4 SEQUENCING AND COMMUNICATION
We would schedule the samples for genomic analysis and would get back to you as soon as possible on the results.