Interpretation of a malady: how scientists zeroed in on one family's rare and crippling disease

posted Apr 21, 2017, 3:19 AM by Vinod Scaria   [ updated Apr 21, 2017, 11:03 PM ]

The poignant story of an Agra family, where six children have the Nalband mutation. Jacob Koshy reports on how a group of scientists linked it to a rare and crippling neurological disease

Read the full text here 

The year of Personal Genomics (The Hindu, Jan01,2017)

posted Jan 4, 2017, 6:47 AM by Vinod Scaria

The conversation around personal genomics amplified in 2016, as did the range of diagnostic options - by Jacob Koshy
Read Full-text here:

Qatar exome study: An advancement in precision medicine (Nature Middle East)

posted Sep 27, 2016, 12:02 AM by Vinod Scaria   [ updated Oct 4, 2016, 2:30 AM ]

By Louise Sarant 

Scientists look at Qataris' exome sequences to anticipate response to two common blood-thinners
The study, by a team from the Delhi-based CSIR Institute of Genomics and Integrative Biology, will be the first that tries to anticipate the reaction of a Qatari patient to a medication based on his or her genetic makeup. The study will appear in Pharmacogenomics
Scientists have used information from the whole-exome sequencing of 100 Qataris to create a comprehensive map of pharmacogenetic variants associated with two anticoagulants.

Should you take that genetic test ? Jacob Koshy (The Hindu May 15, 2016)

posted Jun 28, 2016, 2:48 AM by Vinod Scaria   [ updated Jun 28, 2016, 2:48 AM ]

Why Indians, SE Asian Malays respond differently to some drugs

posted Jun 14, 2016, 9:32 PM by Vinod Scaria

CSIR Young Scientist Award for Biological Sciences

posted Nov 11, 2012, 12:27 AM by Vinod Scaria   [ updated Jun 28, 2016, 2:46 AM ]

Click for High-Res Image

Detailed map of TB genome to help treatment

posted Apr 13, 2012, 1:58 AM by Vinod Scaria   [ updated Apr 13, 2012, 2:01 AM ]

Scientists from all over India have put together a visual map of the tuberculosis bacteria’s genome, a tool that will be freely available and could help researchers in their quest to develop a more accurate treatment for the disease. “The TB genome was sequenced in 1998, but more than 
half the genes in the genome did not have any function attached to them,” said Vinod Scaria, researcher at the Institute of Genomics and Integrative Biology in Delhi and one of the principal investigators for the Open Source Drug Discovery project. “We wanted to collect all the information in one place.” 

Gene card to tell what drugs to avoid

posted Mar 22, 2012, 1:34 AM by Vinod Scaria   [ updated Apr 13, 2012, 2:01 AM ]

New Delhi, April 22: Scientists have launched a project to develop India’s first personal genetic data cards — credit card-sized plastic-and-magnetic devices that could dramatically expand access to personalised predictive medicine

RNA blocker to combat diseases

posted Oct 9, 2011, 5:52 AM by Vinod Scaria

doi:10.1038/nindia.2010.157; Published online 
[10 November 2010 ]

Research highlight

RNA blocker to combat diseases

Researchers have found a new way to block the activity of microRNA (miRNA), a tiny type of RNA that suppresses the expression of certain genes and proteins1. This tiny RNA is present in every type of cell, and has been linked to various conditions such as cancer, schizophrenia, cardiovascular disease and renal function disorders.

This new method of blocking miRNA may open up new avenues for battling a host of diseases. To disrupt the activity of miRNA, the researchers used modified antagomirzymes, known as DNAzymes.

Full-Text at

1-10 of 14