Genomics & Genome Informatics touching lives

We are a group of passionate researchers at the CSIR Institute of Genomics and Integrative Biology (CSIR-IGIB) working towards using advanced Genomics and Data Analytics to understand biology and impact lives around us.

Genetic Epidemiology & Population Genomes

Pathogen Genomics

The recent declaration of COVID-19 as a global pandemic by the World Health Organisation has prompted us to venure into research in this area as well as make the relevant Data, Research and Resources at the Vinod Scaria Lab at CSIR Institute of Genomics and Integrative Biology (CSIR-IGIB) in an open format to ensure that they are widely accessible as well as relevant. The programme would embrace the concepts of open-source and open access.

Learn more at Open COVID-19

COVID-19 and Research on Epidemic Preparedness

COVID-19 Data Open To All

It was as early as January 2020 when Vinod Scaria and his team at Council of Scientific and Industrial Research-Institute of Genomics and Integrative Biology (CSIR-IGIB) knew that the SARS-CoV-2 virus was weeks from hitting India. They had to understand the novel Coronavirus better and fast if diagnostics had to keep pace with the spread. But with the nationwide lockdown, their Delhi lab was shuttered. Of the team of 12, a handful were allowed to work from office. The rest had to manage from home with no infrastructure available to them.


Genetic Epidemiology of Novel and Emerging Pathogens in India

GENEPI is a collaborative programme to use high-throughput genomics approaches to understand the genetic makeup and genetic epidemiology of novel and emerging pathogens in India.

KAISER is a citizen science initiative relying on open science to be able to prepare, understand and respond to epidemics.

This initiative also endeavours to build the much required skill base, resources, data and technologies to be able to help and cater to similar requirements nationally and globally.

Inviting volunteers to join us

Zika VirusGenomics

Recent Publications

Complete list of Publications are available here

Shankar AJ, Jadhao S, Hoy W, McMorran B, Fotte S, Patel H, Scaria V, Nagaraj SH, Pharmacogenomic analysis of a genetically distinct Indigenous populationThe Pharmacogenomics Journal (Accepted 2021)
Rophina M, Pandhare K, Shamnath A, Imran M, Jolly B and Scaria VESC - a comprehensive resource for SARS-CoV-2 immune escape variants. Nucleic Acids Research (2021) Accepted
Gupta A; Bhoyar RC; Mirza S; Jolly B; Senthivel V; Shamnath A; Divakar MK; Imran M; Gupta V; Agrawal SJ; Mukhida S; Sivasubbu S; Scaria VSARS-CoV-2 vaccine breakthrough infection following a previous infection in a healthcare workerJournal of Infection (2021) Accepted
Sehgal P, Mathew S, Sivadas A, Ray A, Tanwar J, Vishwakarma S, Ranjan G, Shamsudheen KV, Bhoyar RC, Pateria A, Leonard E, Lalwani M, Vats A, Pappuru RR, Tyagi M, Jakati S, Sengupta S, B K B, Chakrabarti S, Kaur I, Motiani RK, Scaria V, Sivasubbu S. LncRNA VEAL2 regulates PRKCB2 to modulate endothelial permeability in diabetic retinopathy. EMBO J. 2021 Jun 28:e107134. doi: 10.15252/embj.2020107134.
Mittal G, Anu RI, Vatsyayan A, Pandhare K, Scaria VMUSTARD - a comprehensive resource of Mutation Specific Therapies in Cancer Database (Oxford) 2021 Accepted
Roja Rani P, Imran M, Vijaya Lakshmi J, Jolly B, Afsar S, Jain A, Divakar MK, Suresh P, Sharma D, Rajesh N, Bhoyar RC, Ankaiah D, Shanthi Kumari S, Ranjan G, Anitha Lavanya V, Rophina M, Umadevi S, Sehgal P, Renuka Devi A, Surekha A, Chandra Sekhar P, Hymavathy R, Vanaja PR, Scaria V, Sivasubbu S. Insights from Genomes and Genetic Epidemiology of SARS-CoV-2 isolates from the state of Andhra Pradesh. Epidemiology and Infection. 2021;:1–11.
Sahana S, Sivadas A, Mangla M,et al, Pharmacogenomic landscape of COVID-19 therapies from Indian population genomes. Pharmacogenomics. 2021 Jun 18. doi: 10.2217/pgs-2021-0028. Epub ahead of print. PMID: 34142560.
Cotsapas C, Saarela J, Farmer JR, Scaria V, Abraham RS. Do monogenic inborn errors of immunity cause susceptibility to severe COVID-19? J Clin Invest. 2021 Jun 1:149459. doi: 10.1172/JCI149459 .
Sharma P, Jain A and Scaria V*Genetic landscape of rare autoinflammatory disease variants in Qatar and Middle Eastern populations through the integration of whole-genome and exome datasetsFront. Genet.(2021) Accepted
Ranjan G, Sehgal P, Sharma D, Scaria V, Sivasubbu SFunctional long non-coding and circular RNAs in zebrafishBriefings in Functional Genomics, elab014,
Jain, A, Sharma D, Bajaj, A, Gupta V, Scaria VFounder variants and population genomes—Toward precision medicineAdvances in Genetics (Academic Press) (2021) Accepted
Vatsyayan V, Sharma P, Gupta S, Sandhu S, Venu SL, Sharma V, Badaoui B, Azedine K, Youssef S, Rajab A, Fayez A, Madinur S, Ranawat A, Pandhare K, Ramachandran S, Sivasubbu S, Scaria VDALIA- a comprehensive resource of Disease Alleles in Arab populationPLoS ONE (2021)
Mahadevan R, Bhoyar RC, Viswanathan N, Rajagopal RE, Essaki B, Suroliya V, Chelladurai R, Sankaralingam S, Shanmugam G, Vayanakkan S, Shamim U, Mathur A, Jain A, Imran M, Faruq M, Scaria V, Sivasubbu S, Kalyanaraman SGenomic analysis of patients in a South Indian Community with autosomal dominant cortical tremor, myoclonus and epilepsy suggests a founder repeat expansion mutation in the SAMD12 geneBrain Communications (2021) fcaa214,

Recent Preprints on COVID-19 Research

Rophina, M., Pandhare, K., Mangla, M., Shamnath, A., Jolly, B., Sethi, M., & Scaria, V. FaviCoV -a comprehensive manually curated resource for functional genetic variants in SARS-CoV-2.OSF Preprints (2020, November 17). [Preprint]
Jolly B, Rophina M, Shamnath A, Imran M, Bhoyar RC, Divakar M, Rani PR, Ranjan G, Sehgal P, Chandrasekhar P, Afsar S, Vijaya Lakshmi J, Surekha A, Sivasubbu S, Scaria VGenetic epidemiology of variants associated with immune escape from global SARS-CoV-2 genomesbioRxiv 2020.12.24.424332; doi: [Preprint]
Bhoyar, Rahul C., et al. An Amplicon-based Approach for Sequencing of Sars-cov-2 Using Covidseq Assay on Illumina Miseq Sequencing Platforms.OSF Preprints, 10 May 2021. Web.
Singh, U. B., Rophina, M., Chaudhry, R., Senthivel, V., Bala, K., Bhoyar, R. alGenomic analysis of symptomatic SARS-CoV-2 vaccine breakthrough infections from a tertiary care centre in India. OSF Preprints (2021)

Complete list of COVID-19 Publications are available at Publications page

Talks and Seminars

Archives on the YouTube GenomicsInIndia Channel

Forthcoming talks

Exome Sequence Analysis and Interpretation

Handbook for Clinicians

Vinod Scaria and Sridhar Sivasubbu

Buy on Amazon

The hitchhiker's guide to whole exome analysis

Shrey Gandhi, Vinod Scaria

Buy on Pothy